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The Daily Insight

What is KCO and DLCO?

Author

Olivia Shea

Updated on April 26, 2026

DLCO – The diffusing capacity for carbon monoxide (DLCO) is also known as the transfer factor for carbon monoxide or TLCO. KCO – The carbon monoxide transfer coefficient (KCO is approximately kCO/barometric pressure in mL/minute/ mmHg/L) is often written as DLCO/VA.

What does it mean if DLCO is low?

Low Dlco less than or equal to 50% predicted can predict hypoxemia with exercise. A normal Dlco does not rule out oxygen desaturation with exercise. Reduced Dlco in the context of normal spirometry, lung volumes, and chest radiographs suggests underlying lung disease such as ILD, emphysema, or PAH.

What is DLCO stand for?

Measurement of diffusing capacity of the lungs for carbon monoxide (DLCO), also known as transfer factor, is the second most important pulmonary function test (PFT), after spirometry.

How is DLCO performed?

Diffusing capacity (DLCO) is most commonly measured using the single-breath technique. The patient takes a full inspiration of a gas mixture containing 0.3 percent carbon monoxide and 10 percent helium (the dilution of which provides an index of lung or “alveolar” volume).

What causes decreased DLCO?

There are several conditions that can decrease the DLCO. These include cigarette smoking, emphysema, interstitial lung disease, anemia, decreased lung volume, heart failure, pulmonary vascular disease (pulmonary emboli and pulmonary hypertension), and others.

What causes low DLCO?

Can DLCO improve?

Conclusion: Pulmonary rehabilitation improves oxygenation, severity of dyspnea, exercise capasity and quality of life independent of carbon monoxide diffusion capacity in patents with COPD. Improvement in DLCO in patients with severe diffusion defect suggests that pulmonary rehabilitation reduced mortality.

Why is DLCO low in emphysema?

Causes of Low Diffusing Capacity In contrast, obstructive lung diseases such as emphysema may decrease DLCO by reducing the surface area through which gas can be exchanged. Conditions not related directly to lung function can also result in a decreased surface area available between the alveoli and capillaries.

How do I know if I have DLCO?

In most cases, a lung diffusion test involves the following steps:

  1. A mouthpiece will be placed around your mouth. It will fit snugly.
  2. You’ll take a breath of air.
  3. You’ll hold this air for a count of 10 or so.
  4. You’ll quickly exhale the air you’re holding in your lungs.
  5. This air will be collected and analyzed.

Does exercise improve DLCO?

DLCO increases during exercise, but may not increase adequately if the pulmonary vascular bed is reduced by emphysema.

Can low DLCO improve?

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