Why is mefenamic acid suspended?
Abigail Rogers
Updated on May 01, 2026
Mefenamic acid is used for the short-term treatment of mild to moderate pain from various conditions. It is also used to decrease pain and blood loss from menstrual periods. Mefenamic acid is known as a nonsteroidal anti-inflammatory drug (NSAID).
What is the action of mefenamic acid?
Mefenamic acid has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of mefenamic acid, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro.
What is the contraindication of mefenamic acid?
Mefenamic acid is contraindicated in patients with salicylate hypersensitivity or NSAID hypersensitivity who have experienced asthma, urticaria, or other allergic reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactoid reactions to mefenamic acid have been reported in such patients.
What happens if you take mefenamic acid?
Mefenamic acid can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.
What is Mefenamic acid NHS?
Mefenamic acid is a medicine called a non-steroidal anti-inflammatory drug. It is also known as ‘an NSAID’. Tell your doctor if you have ever had an allergic reaction to any other anti-inflammatory painkiller. Take mefenamic acid with food.
What functional groups are present in mefenamic acid?
Additional Information
| Product No. | D-7733 |
|---|---|
| CAS Number (of the unlabelled compound) | 61-68-7 |
| Shipping Hazards | NON-HAZARDOUS FOR TRANSPORT |
| Category | Pharmaceutical Standards |
| Functional Groups | Amines & Amine Salts,Carboxylic Acids & Salts |
How does mefenamic acid reduce bleeding?
Mefenamic acid works by reducing hormones called prostaglandins in the lining of your uterus (womb). These hormones can cause heavy periods and period pain. Mefenamic acid helps to ease period pain and reduce heavy bleeding from periods, but does not reduce the number of days the period lasts.
Is mefenamic acid contraindicated in pregnancy?
Use of mefenamic acid during pregnancy is not advised unless prescribed by a doctor, especially if you are 30 or more weeks pregnant. Paracetamol is usually recommended to control pain or fever during pregnancy.
Is mefenamic acid bad?
Mefenamic acid may increase your risk of heart problems, including heart attack, stroke, heart failure, or blood clot. These conditions can be fatal. Your risk may increase if you already have heart disease or have taken the medication for a long period of time or at high doses.
What is mefenamic acid used to treat?
Mefenamic acid is used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period). Mefenamic acid is in a class of medications called NSAIDs. It works by stopping the body’s production of a substance that causes pain, fever, and inflammation.
What is the interaction between NSAIDs and mefenamic acid?
The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. mefenamic acid increases levels of pemetrexed by unspecified interaction mechanism. Avoid or Use Alternate Drug.
How does mefenamic acid inhibit prostaglandin synthesis?
Mefenamic acid inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of mefenamic acid.
How to prepare stock solution of mefenamic acid?
The standard Stock solution was prepared by dissolving Mefenamic acid in Sodium Hydroxide Solution separately to get a solution containing 1mg /mL for Mefenamic acid.
