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The Daily Insight

How do you stop the side effects of Bactrim?

Author

Isabella Ramos

Updated on May 03, 2026

If these side effects happen to you, try taking Bactrim (sulfamethoxazole / trimethoprim) with food to help lessen them. If you have diarrhea after taking Bactrim (sulfamethoxazole / trimethoprim), try taking probiotic supplements to help lessen this side effect.

What should you not take with Bactrim?

Common medications that may interact with Bactrim include:

  • anticonvulsants such as phenytoin.
  • antidepressants, such as amitriptyline, amoxapine, and desipramine.
  • cyclosporine.
  • digoxin.
  • anticoagulants (blood thinners), such as warfarin.
  • blood pressure medications, such as captopril or enalapril.
  • indomethacin.
  • pyrimethamine.

Can Bactrim make you sick?

Bactrim DS Tablet can cause nausea, vomiting, stomach pain, loss of appetite, headache, and other side effects. It is recommended that you eat a safe balanced diet and drink plenty of water to prevent any harmful side effects. Contact your doctor right away if any of the side effects escalate.

What should I eat while taking Bactrim?

Take this medication by mouth, as directed by your doctor, with a full glass of water (8 ounces / 240 milliliters). If stomach upset occurs, take with food or milk. Drink plenty of fluids while taking this medication to lower the unlikely risk of kidney stones forming, unless your doctor advises you otherwise.

Is Bactrim well tolerated?

Although the drug is usually well tolerated, it is “associated with several potentially serious adverse reactions,” Ho and Juurlink reported online in CMAJ.

When to stop taking Bactrim?

Stop taking Bactrim and call your doctor right away if you develop a rash after taking Bactrim, and get emergency medical help if the rash starts to become severe or you feel like you are having an allergic reaction.

Is Bactrim a safe antibiotic?

Bactrim (Definition) Trimethoprim and sulfamethoxazole, cotrimoxazole is a combination antibiotic that is used to treat a variety of bacterial infections. Yes: Yes! Yes: All Penicillin are safe in pregnancy Sure b: That combination should be safe. Yes : That is a safe antibiotic.

Is Bactrim harmful to kidneys?

Bactrim may produce incorrect test results if you are monitoring the health of your kidneys with certain tests (such as creatinine). It may also interfere with blood tests to measure methotrexate (Trexall), a drug used to treat certain types of cancer, autoimmune diseases (such as rheumatoid arthritis), and psoriasis.

How long should you take Bactrim for an uti?

The usual adult dose for a urinary tract infection (bladder infection) is 1 Bactrim DS (double strength) tablet twice daily for 10 to 14 days.